Feb 14, 2008 - Accu-Break Pharmaceuticals, Inc. ("ABP"), a company with a suite of pharmaceutical tablet technologies for creating divisible dosage forms, announced today the recent issuance of two patents covering its Accu-Break technologies. Tablets made in the Accu-Break format contain a drug-free layer that may be used as a break zone should the dose need to be adjusted. The technologies are intended to create pharmaceutical tablets that can be easily divided into precise doses to facilitate titration, dose adjustment and individualized dosing.
The first patent (U.S. 7,318,935) claims a layered immediate-release (IR) tablet having at least two different active ingredients segregated from each other by a drug-free layer. The innovative tablet design may be used to combine medications in a way that allows them to be administered together in a single tablet, as in traditional fixed-dose combination tablets, but also enables the two medications to be accurately separated if medically indicated simply by splitting the tablet through the drug-free layer. The invention also allows for the combination of active ingredients within a single tablet that are incompatible, providing a potential solution for useful combinations containing formulations that may be difficult to combine in a single tablet due to incompatibility reasons, among others.
The second patent (U.S. 7,329,418) also claims divisible tablets, but involves the creation of tablets that contain a half dose of the same active (or combination of the same actives) on each end of the tablet, separated by a drug-free break layer. Division of these tablets through the drug-free break layer would provide an accurate partial dose of the active(s), useful for titration and dose adjustment.
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